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Installing htmx can be as simple as adding a <script> tag to an HTML page that loads htmx from a global CDN, like this:
<script src="https://unpkg.com/htmx.org@1.9.9"></script>
You can also save the htmx code locally on your website and load it from there. Or reference https://unpkg.com/htmx.org which gives you the latest version (but adds a redirect) - if you choose this route it’s probably safer to use https://unpkg.com/htmx.org@1 to stick to htmx 1.x in case 2.x is released with breaking changes.
In a modern site built for example with Astro you typically do this in a common layout component, but you can start simple and add it to a simple index.html page that you then load in the browser from your local filesystem.
You can also install htmx using npm to add it to your build system and use the import syntax to load it:
npm install htmx.org
//....in your code...
import 'htmx.org'
But I think the <script> tag approach is best suited for htmx.